What Is CRRT？
CRRT (Continuous Renal Replacement Therapy) devices mimic the function of human kidneys by continuously removing accumulated toxins, metabolic wastes, and excess water from the patient's body through the mechanisms of dialysis and filtration, while maintaining electrolyte and acid-base balances and supplementing with essential nutrients as needed.
Components of CRRT Machine
Blood Circuit
Filters
Rehydration system
Anticoagulation system
Monitoring System
Drainage system
Main functions of the CRRT Machine
toxin removal
Small and medium molecule toxins: such as urea, creatinine and uric acid, metabolic wastes that are the main accumulators in renal insufficiency.
Macromolecular toxins: Certain therapeutic modalities (e.g., hyperpermeable filtration) also remove inflammatory mediators, endotoxins, and other macromolecules, reducing systemic inflammatory response syndrome (SIRS).
Fluid Management
Dehydration: removes excess water due to renal failure, reduces cardiopulmonary burden, and improves tissue perfusion.
Fluid Replacement: While purifying the blood, the body is replenished with necessary fluids through replacement fluids to prevent excessive dehydration.
Correction of hydroelectrolyte disturbances: e.g., hyperkalemia and hyponatremia, with precise management achieved by adjusting the composition of dialysate and replacement fluids.
Acid-base balance adjustment
Acidosis correction: reduction of the accumulation of acidic metabolites in the body by bicarbonate supplementation in the dialysis solution.
Correction of alkalosis: adjustment of dialysate formulation to reduce bicarbonate concentration or removal of excess alkaline components by filtration.
Our CRRT equipment
CNME040109
Six Pumps, including one Heparin Pump, with four scales, 14 treatment modes (CVVHD, CVVH, CVVHDF, SCUF, HP, PE, PA, CPFA, MARS, FPSA, SPAD, DFPP, RAD, PDF, RCA-regional citrate anticoagulation, Replacement fluid dual channel input)
CNME040109A
Five Pumps, including one Heparin Pump, with three scales, 7 treatment modes (CVVHD, CVVH, CVVHDF, SCUF, HP, PE, PA, RCA-regional citrate), and a single pump (CVVHD, CVVH, CVVHDF, SCUF, HP, PE, PA, RCA-regional citrate anticoagulation, Replacement fluid dual channel input)
CNME040109B
Four Pumps, including one Heparin Pump, with two scales, 6 treatment modes (CVVHD, CVVH, SCUF, HP, PE, PA)
Differences between CRRT and hemodialysis
Continuous Renal Replacement Therapy (CRRT) and Hemodialysis (HD) are both common modalities of blood purification.CRRT is a novel treatment while HD is a traditional method and both have their own characteristics.
CRRT |
HD | |
|---|---|---|
Working Principle | Simulating the physiological mechanism of glomerular filtration and tubular reabsorption, it adopts convective mode to slowly remove toxins, metabolic wastes and inflammatory factors from the blood, and it can remove medium and small molecules at the same time, which has less impact on hemodynamics, and it is more suitable for patients with unstable blood pressure. | Through the principle of diffusion of metabolic waste and excess water in the blood through the dialyzer removed back to the body, the main needle for small molecule toxin removal effect is better |
Population | Applied to CCU, ICU and other critical patient treatment places, suitable for poor heart function or serious condition of patients, such as acute renal insufficiency, cardiac insufficiency, multi-organ failure syndrome, cerebral edema and drug poisoning and other conditions | For patients in more stable states, such as chronic renal failure, acute kidney injury, acute heart failure, metabolic acidosis, uremia, or poisoning from drugs and poisons (e.g., ethanol, salicylates) |
Range Of Toxin Removal | Removes small molecule toxins on top of medium molecule toxins, cytokines and inflammatory mediators, helping to improve the systemic inflammatory state | Removes small molecule metabolic wastes such as creatinine and urea nitrogen from the body |
Dialysis Duration | Continuous treatment with a minimum treatment time of 8 hours and continuous 24-hour uninterrupted operation | Intermittent treatment, a single session lasting 4-6 hours, usually performed about 3 times a week |
Blood Flow Rate | Low blood flow, usually between 100-200 ml/min | Higher blood flow, usually between 300-500 ml/min |
Contraindications to CRRT devices
Absolute contraindications
Uncontrollable Hemorrhage: Because CRRT requires continuous anticoagulation, use of CRRT may further exacerbate the risk of bleeding if the patient has active bleeding that cannot be controlled by pharmacologic or surgical intervention.
Severe Coagulation Disorders: e.g., severe deficiencies of coagulation factors or severe thrombocytopenia, the use of CRRT may lead to bleeding complications.
Relative Contraindications
Extreme Hemodynamic instability: although CRRT has a small hemodynamic impact, patients who are in a state of extreme hypotension and cannot be stabilized by antihypertensive medications may not be able to tolerate the altered circulation.
No Viable Vascular Access: CRRT requires stable vascular access to maintain circulation, and if a patient is unable to establish effective vascular access due to anatomical or pathologic reasons, treatment cannot proceed.
Special Circumstances
End-Stage Malignancies: the applicability of CRRT should be carefully weighed in patients with a short life expectancy and no apparent therapeutic benefit.
Severe Heart Failure: some patients may have difficulty tolerating minor hemodynamic fluctuations during CRRT therapy due to extreme cardiac failure.
No Clear Therapeutic Goal: If the therapeutic goal of CRRT cannot be clarified, e.g., to improve prognosis or to maintain life, prudent consideration should be given to whether to intervene.